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doi: 10.1038/s41598-018-37485-8

Cells 9:1489

Fetoplacental metabolic stress induces epigenetic reprogramming (such as 5-methylcytosine and N 6 -methyladenosine modifications), linking tissue progenitors to adult insulin resistance and developmental origins of adult-onset metabolic syndrome

HIF-1, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas